Systemic Enzyme Alternative to NSAIDs

Joint pain and inflammation may have many causes. For some, the aches flare up with cold weather. For others, it may be an acute reaction to over-extension, strains and sprains. For still others, it may be a more chronic condition like osteoarthritis or rheumatoid arthritis. Regardless of the cause, for millions of people suffering from stiff, sore and swollen joints, the standard treatment tends to be treating the symptoms with NSAIDs (non-steroidal anti-inflammatory drugs).

Of course, NSAIDs are drugs and as such, have their own drawbacks. For example, the possible side effects of NSAIDs include headaches, dizziness, ringing in the ears and gastrointestinal problems, like occult bleeding and potentially even ulceration. In addition, there is evidence that NSAIDs may inhibit the repair of the cartilage that, in turn, may worsen the progression of the condition. As a result, the search for an appropriate analgesic, anti-inflammatory continues.

The anti-inflammatory effect of systemic proteolytic enzymes is well known and has been in use for over 50 years.1 Fortunately, proteolytic enzymes are well-tolerated and not associated with any significant side effects. The next step in systemic enzyme therapy was to find the most effective and well researched systemic enzyme blend to effectively address both the symptoms and causes of inflammation and pain.

Proteolytic enzymes not only possess potent anti-inflammatory activity, but also reduces edema2 and has significant fibrinolytic activity.3 It is unusually effective with the symptoms of osteo- and rheumatoid arthritis. Rheumatoid arthritis is especially difficult since it is an autoimmune disorder and powerful anti-inflammatory drugs are commonly  used to reduce the symptoms. The side effects are often dramatic and even intolerable. Clinical studies have demonstrated that systemic proteolytic enzymes, like those in Exclzyme, effectively reduce symptoms as well or better than NSAIDs and without the untoward side effects.4,5



1.  Ambrus JL, et al. Absorption of exogenous and endogenous proteolytic enzymes. Clin Pharmacol Therap 1967; 8:362-8.
2.  Esch PM, Gerngross H, Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase – a prospective study (German). Fortschr Med. 1989; 107(4):67-8,71-2.
3.  Tachibana M, Mizukoshi O, et al. A multi-centre, double-blind study of Serratiopeptidase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica. 1984; 3(8):526-30.
4.  Ransberger K. Enzyme treatment of immune complex diseases. Arthritis Rheuma. 1986; 8:16-9.
5.  Steffen C, et al. Enzyme therapy in comparison with immune complex determinations in chronic polyarteritis. Rheumatologie. 1985; 44:51-6.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s